Inside Cover: A 5′‐Cap for DNA Probes Binding RNA Target Strands (Chem. Eur. J. 42/2011) | Zendy

Egetenmeyer Simone | Zendy; Richert Clemens | Zendy

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Inside Cover: A 5′‐Cap for DNA Probes Binding RNA Target Strands (Chem. Eur. J. 42/2011)

Author(s) -

Egetenmeyer Simone,

Richert Clemens

Publication year - 2011

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201190206

Subject(s) - oligonucleotide , base pair , dna , rna , chemistry , covalent bond , cover (algebra) , helix (gastropod) , biophysics , selectivity , biochemistry , biology , gene , engineering , mechanical engineering , ecology , organic chemistry , snail , catalysis

To cap or not to cap? In their Full Paper on page 11813 ff. , S. Egetenmeyer and C. Richert describe a covalently attached cap for the 5′‐terminus of oligonucleotides that increases base pairing fidelity by binding tightly to the helix when a canonical base pair is formed, but providing little stabilization in the case of a mismatch. The resulting enhancement in affinity and selectivity aids the detection of microRNAs.

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