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Cover Picture: Kinetic Studies on the Reaction between Cob(I)alamin and Peroxynitrite: Rapid Oxidation of Cob(I)alamin to Cob(II)alamin by Peroxynitrous Acid / Mechanistic Studies on the Reaction between Cob(II)alamin and Peroxynitrite: Evidence for a Dual Role for Cob(II)alamin as a Scavenger of Peroxynitrous Acid and Nitrogen Dioxide (Chem. Eur. J. 42/2011)
Author(s) -
Mukherjee Riya,
Brasch Nicola E.,
Mukherjee Riya,
Brasch Nicola E.
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201190205
Subject(s) - peroxynitrite , chemistry , peroxynitrous acid , cofactor , electron transport chain , intracellular , enzyme , hydroxocobalamin , biochemistry , photochemistry , vitamin b12 , cyanocobalamin , superoxide
Vitamin B 12 (cobalamin) is an essential cofactor in all mammalian cells. Reduced cobalamins, cob(I)alamin (Co I ) and cob(II)alamin (Co II ), are intracellular precursors of the B 12 cofactor forms. Both mammalian B 12 ‐dependent enzyme reactions are inactivated under oxidative stress conditions. Elevated levels of the potent reactive oxygen species peroxynitrite, formed by the diffusion‐controlled reaction between . NO and O 2 .− , are associated with multiple chronic inflammatory diseases. The cover—designed by Frank Mueller—shows that peroxynitrite rapidly oxidizes cob(I)alamin and cob(II)alamin to inactive cob(III)alamins. More details are given in the Communication and Full Paper by R. Mukherjee and N. E. Brasch on pages 11723 ff. and 11805 ff. , respectively.