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Cover Picture: Luminescent Rhenium(I) Polypyridine Complexes Appended with an α‐ D ‐Glucose Moiety as Novel Biomolecular and Cellular Probes (Chem. Eur. J. 30/2011)
Author(s) -
Louie ManWai,
Liu HuaWei,
Lam Marco HoChuen,
Lam YunWah,
Lo Kenneth KamWing
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201190149
Subject(s) - chemistry , moiety , rhenium , nucleophile , aryl , stereochemistry , biochemistry , organic chemistry , catalysis , alkyl
Malignant cell growth is strongly dependent on increased glucose uptake and metabolism, which is usually attributed to the higher expression levels of glucose transporters (GLUTs) in these cells compared to normal cells. In their Communication on page 8304 ff. , K. K.‐W. Lo and co‐workers describe new luminescent rhenium(I) polypyridine complexes modified with an α‐ D ‐glucose moiety. The much higher cellular uptake of these complexes (the glowing grapes in the cover picture) by cancer cells (devil) compared to normal cells (angels), together with a range of other experimental results in this study, indicate that the uptake of these glucose complexes is mediated by GLUTs. Mr. Michael Wai‐Lun Chiang is acknowledged for the cover picture design.