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Cover Picture: A Novel and Convenient Synthesis of Benzonitriles: Electrophilic Cyanation of Aryl and Heteroaryl Bromides (Chem. Eur. J. 15/2011)
Author(s) -
Anbarasan Pazhamalai,
Neumann Helfried,
Beller Matthias
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201190071
Subject(s) - cyanation , electrophile , aryl , chemistry , reagent , steric effects , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , alkyl
Electrophilic cyanation of aryl and heteroaryl bromides provides a convenient route to a variety of benzonitriles. N ‐Cyano‐ N ‐phenyl‐ p ‐methylbenzenesulfonamide serves as a more benign electrophilic cyanation reagent in these reactions, in which electronically different and sterically demanding aryl bromides are successfully cyanated in good to excellent yields. Details of the synthesis and its application to interesting pharmaceutical targets are described in the Full Paper by M. Beller and co‐workers on page 4217 ff.