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Cover Picture: Chloropupukeanolides C–E: Cytotoxic Pupukeanane Chlorides with a Spiroketal Skeleton from Pestalotiopsis fici (Chem. Eur. J. 9/2011)
Author(s) -
Liu Ling,
Bruhn Torsten,
Guo Liangdong,
Götz Daniel C. G.,
Brun Reto,
Stich August,
Che Yongsheng,
Bringmann Gerhard
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201190039
Subject(s) - chemistry , pyrophosphate , stereochemistry , crystallography , combinatorial chemistry , enzyme , organic chemistry
Terrestrial sources for a novel spiroketal skeleton derived from the chlorinated tricyclo‐[4.3.1.0 3, 7 ]‐decane (pupukeanane) and the 2,6‐dihydroxy‐4‐methylbenzoic acid moieties were found in three highly functionalized secondary metabolites, that is, chloropupukeanolides C–E. G. Bringmann, Y. Che et al. describe the structure determination of these and other metabolites isolated from the scale‐up fermentation extract of the plant endophytic fungus Pestalotiopsis fici in their Full Paper on page 2604 ff.