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[Pd(IPr*)(cinnamyl)Cl]: An Efficient Pre‐catalyst for the Preparation of Tetra‐ ortho ‐substituted Biaryls by Suzuki–Miyaura Cross‐Coupling
Author(s) -
Chartoire Anthony,
Lesieur Mathieu,
Falivene Laura,
Slawin Alexandra M. Z.,
Cavallo Luigi,
Cazin Catherine S. J.,
Nolan Steven P.
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201104009
Subject(s) - tetra , carbene , catalysis , reactivity (psychology) , chemistry , combinatorial chemistry , coupling reaction , medicinal chemistry , coupling (piping) , organic chemistry , materials science , medicine , alternative medicine , pathology , metallurgy
The bigger the better : The new well‐defined [Pd(IPr*)(cin)Cl] pre‐catalyst is described (see scheme). This complex proves to be highly active in the Suzuki–Miyaura cross‐coupling for the synthesis of tetra‐ ortho ‐substituted biaryls under mild conditions. IPr* is reported as the largest N ‐heterocyclic carbene (NHC) to date for [Pd(NHC)(cin)Cl] complexes, explaining the high reactivity observed for this complex in this challenging transformation.