[Pd(IPr*)(cinnamyl)Cl]: An Efficient Pre‐catalyst for the Preparation of Tetra‐ ortho ‐substituted Biaryls by Suzuki–Miyaura Cross‐Coupling | Zendy

Chartoire Anthony | Zendy; Lesieur Mathieu | Zendy; Falivene Laura | Zendy; Slawin Alexandra M. Z. | Zendy; Cavallo Luigi | Zendy; Cazin Catherine S. J. | Zendy; Nolan Steven P. | Zendy

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[Pd(IPr*)(cinnamyl)Cl]: An Efficient Pre‐catalyst for the Preparation of Tetra‐ ortho ‐substituted Biaryls by Suzuki–Miyaura Cross‐Coupling

Author(s) -

Chartoire Anthony,

Lesieur Mathieu,

Falivene Laura,

Slawin Alexandra M. Z.,

Cavallo Luigi,

Cazin Catherine S. J.,

Nolan Steven P.

Publication year - 2012

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201104009

Subject(s) - tetra , carbene , catalysis , reactivity (psychology) , chemistry , combinatorial chemistry , coupling reaction , medicinal chemistry , coupling (piping) , organic chemistry , materials science , medicine , alternative medicine , pathology , metallurgy

The bigger the better : The new well‐defined [Pd(IPr*)(cin)Cl] pre‐catalyst is described (see scheme). This complex proves to be highly active in the Suzuki–Miyaura cross‐coupling for the synthesis of tetra‐ ortho ‐substituted biaryls under mild conditions. IPr* is reported as the largest N ‐heterocyclic carbene (NHC) to date for [Pd(NHC)(cin)Cl] complexes, explaining the high reactivity observed for this complex in this challenging transformation.

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