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Diffusion and Birefringence of Bioactive Dyes in a Supramolecular Guanosine Hydrogel
Author(s) -
Das Rabindra Nath,
Kumar Y. Pavan,
Pagoti Sreenivasarao,
Patil Avinash J.,
Dash Jyotirmayee
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103814
Subject(s) - guanosine , self healing hydrogels , rhodamine b , birefringence , supramolecular chemistry , materials science , nanofiber , diffusion , chemical engineering , rhodamine , chemistry , polymer chemistry , fluorescence , nanotechnology , organic chemistry , molecule , biochemistry , physics , photocatalysis , quantum mechanics , engineering , thermodynamics , catalysis
Transparent self‐standing supramolecular hydrogels were readily prepared by the potassium‐ion‐mediated self‐organization of guanosine and 8‐bromoguanosine whilst the individual components precipitated within a few hours. VT‐NMR spectroscopy showed that bromoguanosine was a superior gelator compared to guanosine. XRD analysis showed that gel formation was caused by stacked G‐quartets. AFM analysis revealed dendritic architectures of the nanofibers in the two‐component hydrogel network. DSC profiles showed that the hybrid hydrogels underwent sol–gel transition at lower temperature than the pure guanosine and bromoguanosine hydrogels. Interestingly, bioactive dyes, such as rose bengal, rhodamine‐6‐G, and fluorescein, could be diffused and released in a controlled manner. UV/Vis absorption and fluorescence spectroscopy and CLSM were used to investigate the diffusion behavior of dyes in the hydrogel network. These dyes exhibited strong birefringence in the gel network (0.07–0.1) as a result of the anisotropic organization.