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Aryl Ether as a Negishi Coupling Partner: An Approach for Constructing CC Bonds under Mild Conditions
Author(s) -
Wang Chao,
Ozaki Takashi,
Takita Ryo,
Uchiyama Masanobu
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103784
Subject(s) - negishi coupling , aryl , ether , bond , coupling (piping) , chemistry , materials science , organic chemistry , business , composite material , alkyl , catalysis , finance
An etheric Negishi coupling : The first cross‐coupling reaction between aryl alkyl ethers and dianion‐type zincate reagents to afford biaryl compounds through selective cleavage of the etheric C(sp 2 )O bond was developed. Dianion‐type zincates showed excellent reactivity toward the aromatic ethers under mild conditions, with good functional group compatibility (see scheme).