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Oxidative Mizoroki–Heck‐Type Reaction of Arylsulfonyl Hydrazides for a Highly Regio‐ and Stereoselective Synthesis of Polysubstituted Alkenes
Author(s) -
Yang FuLai,
Ma XianTao,
Tian ShiKai
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103671
Subject(s) - chemistry , stereoselectivity , aryl , amide , oxidative phosphorylation , alkoxy group , organic chemistry , sulfonamide , alcohol , combinatorial chemistry , catalysis , biochemistry , alkyl
A useful source : Arylsulfonyl hydrazides have been identified as synthetically useful aryl sources for the Pd(OAc) 2 catalyzed oxidative Mizoroki–Heck‐type reaction under molecular oxygen to provide a convenient access to polysubstituted alkenes in a highly regio‐ and stereoselective manner (see scheme). The reaction well tolerates various functional groups such as alkoxy, halo, alcohol, carboxylic acid, ester, amide, sulfonamide, and sulfone.