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Gold(I)‐Catalyzed Unprecedented Rearrangement Reaction Between 2‐Aminobenzaldehydes with Propargyl Amines: An Expedient Route to 3‐Aminoquinolines
Author(s) -
Patil Nitin T.,
Raut Vivek S.,
Shinde Valmik S.,
Gayatri Gaddamanugu,
Sastry G. Narahari
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103668
Subject(s) - propargyl , amine gas treating , aminoquinolines , computer science , catalysis , combinatorial chemistry , chemistry , organic chemistry
Access to aminoquinolines : A gold(I)‐catalyzed unprecedented rearrangement reaction between 2‐aminobenzaldehydes with propargyl amine was studied. The study provided, for the first time, direct access to 3‐aminoquinolines in one step starting from readily available starting materials (see scheme). Elegantly designed experiments were employed to unravel the mechanism of this unprecedented rearrangement, which are corroborated by DFT calculations.