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A Uniform Sub‐50 nm‐Sized Magnetic/Upconversion Fluorescent Bimodal Imaging Agent Capable of Generating Singlet Oxygen by Using a 980 nm Laser
Author(s) -
Chen Feng,
Zhang Shengjian,
Bu Wenbo,
Chen Yu,
Xiao Qingfeng,
Liu Jianan,
Xing Huaiyong,
Zhou Liangping,
Peng Weijun,
Shi Jianlin
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103611
Subject(s) - photodynamic therapy , singlet oxygen , photon upconversion , materials science , fluorescence , microemulsion , methylene blue , photochemistry , nanotechnology , drug delivery , laser , chemistry , optoelectronics , photocatalysis , doping , oxygen , optics , organic chemistry , pulmonary surfactant , biochemistry , physics , catalysis
Abstract Upconverting nanoparticles (UCNPs) with fascinating properties hold great potential as nanotransducers for solving the problems that traditional photodynamic therapy (PDT) has been facing. In this report, by using well‐selected bifunctional gadolinium (Gd)‐ion‐doped UCNPs and water‐soluble methylene blue (MB) combined with the water‐in‐oil reverse microemulsion technique, we have succeeded in developing a new kind of UCNP/MB‐based PDT drug, NaYF 4 :Er/Yb/Gd@SiO 2 (MB), with a particle diameter less than 50 nm. Great efforts have been made to investigate the drug‐formation mechanism and provide detailed physical and photochemical characterizations and the potential structure optimization of the as‐designed PDT drug. We envision that such a PDT drug will become a potential theranostic nanomedicine for future near‐infrared laser‐triggered photodynamic therapy and simultaneous magnetic/optical bimodal imaging.