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pH‐ and Redox‐Responsive Polysaccharide‐Based Microcapsules with Autofluorescence for Biomedical Applications
Author(s) -
Gao Liang,
Fei Jinbo,
Zhao Jie,
Cui Wei,
Cui Yue,
Li Junbai
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103584
Subject(s) - cystamine , polysaccharide , covalent bond , chemistry , intracellular , redox , disulfide bond , nanotechnology , combinatorial chemistry , biophysics , materials science , biochemistry , organic chemistry , biology
Autofluorescent microcapsules were assembled by covalent cross‐linking of polysaccharide alginate dialdehyde (ADA) derivative and cystamine dihydrochloride (CM) through a layer‐by‐layer (LBL) technique. The formulated Schiff base and disulfide bonds render capsules with pH‐ and redox‐responsive properties for pinpointed intracellular delivery based on the physiological difference between intracellular and extracellular environments. This simple and versatile method could be extended to other polysaccharide derivatives for the fabrication of autofluorescent nano‐ and micromaterials with dual stimuli response for biomedical applications.