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Snapshot of the Palladium(II)‐Catalyzed Oxidative Biaryl Bond Formation by X‐ray Analysis of the Intermediate Diaryl Palladium(II) Complex
Author(s) -
Gensch Tobias,
Rönnefahrt Marika,
Czerwonka Regina,
Jäger Anne,
Kataeva Olga,
Bauer Ingmar,
Knölker HansJoachim
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103576
Subject(s) - palladium , oxidative addition , chemistry , catalysis , oxidative phosphorylation , x ray , combinatorial chemistry , crystal structure , stereochemistry , medicinal chemistry , crystallography , organic chemistry , physics , biochemistry , quantum mechanics
Pd II caught in the act : The diaryl Pd II intermediate of a Pd II ‐catalyzed oxidative biaryl bond formation proceeding via a double CH bond activation has been isolated and fully characterized, including an X‐ray crystal structure analysis (see figure). Stabilization due to chelation by adjacent pivaloyloxy and acetyl groups has allowed the isolation of this long‐sought crucial intermediate. On gentle warming, the complex is transformed into a carbazole product, and the catalytically active Pd II species is regenerated by oxidation with Cu II .