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TRAP, a Powerful and Versatile Framework for Gallium‐68 Radiopharmaceuticals
Author(s) -
Notni Johannes,
Šimeček Jakub,
Hermann Petr,
Wester HansJürgen
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103503
Subject(s) - gallium , trap (plumbing) , chelation , combinatorial chemistry , nanotechnology , positron emission tomography , chemistry , materials science , inorganic chemistry , physics , organic chemistry , nuclear medicine , medicine , meteorology
A veritable gallium TRAP : Triazacyclononane‐phosphinic acid chelators (TRAP) form highly stable complexes with Ga 3+ (see figure) extremely efficiently over a wide pH range. Homo‐ and heteromultimeric bioconjugates can be synthesized in a straightforward manner, all of which renders TRAP a chelator with ideal properties for 68 Ga positron emission tomography (PET) imaging agent elaboration.