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A Convenient and Practical Synthesis of Anisoles and Deuterated Anisoles by Palladium‐Catalyzed Coupling Reactions of Aryl Bromides and Chlorides
Author(s) -
Gowrisankar Saravanan,
Neumann Helfried,
Beller Matthias
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103347
Subject(s) - anisole , aryl , deuterium , chemistry , catalysis , halide , palladium , coupling (piping) , methanol , combinatorial chemistry , organic chemistry , medicinal chemistry , materials science , physics , alkyl , quantum mechanics , metallurgy
Synthesis of anisole : Aryl and heteroaryl halides undergo selective CO cross‐coupling reactions with methanol in the presence of a Pd(OAc) 2 / L3 catalyst system. The corresponding ethers were obtained under mild conditions in good yields. The catalytic methodology was also used for the synthesis of labeled deuterated anisoles in good yields (see scheme).