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Total Synthesis of Polyene Natural Product Dihydroxerulin by Mild Organocatalyzed Dehydrogenation of Alcohols
Author(s) -
Xie Hexin,
Zhang Shilei,
Li Hao,
Zhang Xinshuai,
Zhao Sihan,
Xu Zian,
Song Xixi,
Yu Xinhong,
Wang Wei
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103325
Subject(s) - polyene , dehydrogenation , natural product , chemistry , organic chemistry , total synthesis , product (mathematics) , combinatorial chemistry , catalysis , mathematics , geometry
Polyene synthesis : An efficient approach to the total synthesis of polyene natural product dihydroxrulin ( 1 ) is described. A novel, mild, direct organocatalytic IBX‐mediated dehydrogenation process of simple alcohols to enals has been developed, which serves as a key step in the synthesis (see scheme).
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