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The First Well‐Defined Silver(I)‐Complex‐Catalyzed Cycloaddition of Azides onto Terminal Alkynes at Room Temperature
Author(s) -
McNulty James,
Keskar Kunal,
Vemula Ramesh
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103244
Subject(s) - cycloaddition , alkyne , azide , combinatorial chemistry , catalysis , chemistry , computer science , click chemistry , scheme (mathematics) , organic chemistry , mathematics , mathematical analysis
Silver(I)‐catalyzed click chemistry : Substituted 1,2,3‐triazoles are versatile intermediates with an expanding array of applications. The discovery and application of a general Ag I ‐catalyzed azide–alkyne cycloaddition reaction (AAC) leading to 1,2,3‐triazoles is reported. The synthesis of a stable, well‐defined Ag I complex of type [Ag I (L 2 )(OAc)] is described, along with the unprecedented ability of this complex to promote the general Ag‐AAC at room temperature (see scheme).