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Synthesis of Trifluorostyrene Derivatives by Palladium‐Catalyzed Cross‐Coupling of Lithium Trimethoxy(trifluorovinyl)borate with Aryl Bromides
Author(s) -
Duric Sasa,
Schmidt Bernd M.,
Ninnemann Nina M.,
Lentz Dieter,
Tzschucke C. Christoph
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103067
Subject(s) - aryl , reagent , bromine , palladium , boron , chemistry , lithium (medication) , bromide , catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry , psychology , alkyl , psychiatry
Fluor‐ing it : The stable, crystalline trimethoxy(trifluorovinyl)borate is a convenient reagent for efficiently displacing a bromine atom with a trifluorovinyl group (see scheme). This Suzuki coupling reaction significantly simplifies the route to trifluorostyrenes, which might be interesting compounds for materials science or medicinal chemistry.