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Photoredox‐Initiated α‐Alkylation of Imines through a Three‐Component Radical/Cationic Reaction
Author(s) -
Courant Thibaut,
Masson Géraldine
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103062
Subject(s) - alkylation , chemistry , cationic polymerization , imine , photoredox catalysis , component (thermodynamics) , radical , polar , photochemistry , organic chemistry , catalysis , photocatalysis , physics , astronomy , thermodynamics
Radical‐polar crossover reaction : The photoredox‐mediated alkylation of enamides with diethyl bromomalonate in the presence of alcohols has been developed. This multicomponent domino process affords β‐alkylated α‐carbamido ethers as stables imine surrogates in good to excellent yields under mild conditions (see scheme).