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Supramolecular Dendrimers: Convenient Synthesis by Programmed Self‐Assembly and Tunable Thermoresponsivity
Author(s) -
Ghosh Partha S.,
Hamilton Andrew D.
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103051
Subject(s) - dendrimer , supramolecular chemistry , non covalent interactions , oligonucleotide , click chemistry , chemistry , supramolecular assembly , nanotechnology , combinatorial chemistry , self assembly , materials science , molecule , polymer chemistry , organic chemistry , dna , hydrogen bond , biochemistry
We report here the noncovalent synthesis of thermosensitive dendrimers. Short oligoguanosine strands were linked to the focal point of a dendron by using “click chemistry”, and quadruplex formation was used to drive the self‐assembly process in the presence of metal ions. The dynamic nature of these noncovalent assemblies can be exploited to create combinatorial libraries of dendrimers as demonstrated by the co‐assembly of two components. These supramolecular dendrimers showed thermoresponsive behavior that can be tuned by varying the templating cations or the number of guanines in the oligonucleotide strand.