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Biphenyl‐Based Diaminophosphine Oxides as Air‐Stable Preligands for the Nickel‐Catalyzed Kumada–Tamao–Corriu Coupling of Deactivated Aryl Chlorides, Fluorides, and Tosylates
Author(s) -
Jin Zhong,
Li YanJing,
Ma YongQiang,
Qiu LingLing,
Fang JianXin
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103050
Subject(s) - aryl , biphenyl , catalysis , nickel , bimetallic strip , reagent , chemistry , benzene , combinatorial chemistry , coupling (piping) , organic chemistry , materials science , alkyl , metallurgy
A cooperative couple : Cooperative bimetallic activation of CF and CO bonds gave rise to easy coupling with aryl fluorides and tosylates. Novel air‐ and moisture‐stable diaminophosphine oxides derived from 1,1′‐biphenyl‐2,2′‐diamine proved to be versatile preligands for the nickel‐catalyzed cross‐coupling of aryl Grignard reagents with a variety of deactivated aryl chlorides, fluorides, and tosylates (see scheme).