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New Ruthenium(II) Complexes Functionalized with Coumarin Derivatives: Synthesis, Energy‐Transfer‐Based Sensing of Esterase, Cytotoxicity, and Imaging Studies
Author(s) -
Li MeiJin,
Wong Keith ManChung,
Yi Changqing,
Yam Vivian WingWah
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103025
Subject(s) - ruthenium , coumarin , cytotoxicity , chemistry , luminescence , bipyridine , energy transfer , esterase , photochemistry , combinatorial chemistry , organic chemistry , materials science , enzyme , in vitro , biochemistry , optoelectronics , molecular physics , crystal structure , catalysis
Two new bichromophoric ruthenium(II) complexes, [Ru(bpy) 2 (bpy‐CM)](PF 6 ) 2 and [Ru(bpy) 2 (bpy‐CM343)](PF 6 ) 2 (bpy=2,2′‐bipyridine, CM=coumarin) with appended coumarin ligands have been designed and synthesized. The energy‐transfer‐based sensing of esterase by the complexes has been studied by using UV/Vis and luminescence spectroscopic methods. The cytotoxicity and the cellular uptake of one of the complexes have also been investigated.