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A Ratiometric and Targetable Fluorescent Sensor for Quantification of Mitochondrial Zinc Ions
Author(s) -
Xue Lin,
Li Guoping,
Yu Cailan,
Jiang Hua
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201103007
Subject(s) - fluorescence , zinc , mitochondrion , chemistry , computer science , computational biology , biophysics , combinatorial chemistry , biochemistry , biology , physics , optics , organic chemistry
Trapping in mitochondria : A ratiometric fluorescent sensor for the detection of mitochondrial Zn 2+ was synthesised and evaluated on the basis of inhibition of resonance. The sensor, with good selectivity and high sensitivity, can quantify the free Zn 2+ level in mitochondria, and can be used to visualise the mitochondrial Zn 2+ change in living cells (see figure).