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Pd‐Catalyzed Multiple CH Functionalization to Construct Biologically Active Compounds from Aryl Aldoxime Ethers with Arenes
Author(s) -
Thirunavukkarasu Vedhagiri S.,
Cheng ChienHong
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201102996
Subject(s) - chemistry , catalysis , aryl , palladium , combinatorial chemistry , construct (python library) , organic chemistry , medicinal chemistry , computer science , alkyl , programming language
Functional fluorenones : Aromatic aldoxime ethers react with unactivated arenes catalyzed by palladium complexes to give biologically active fluoren‐9‐ones (see scheme). Multiple CH bond activation and an oxidative cyclization are involved in the reaction.