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Kinetic Differentiation between Homo‐ and Alternating AT DNA by Sterically Restricted Phosphonium Dyes
Author(s) -
Tumir LidijaMarija,
Crnolatac Ivo,
Deligeorgiev Todor,
Vasilev Aleksey,
Kaloyanova Stefka,
Grabar Branilović Marina,
Tomić Sanja,
Piantanida Ivo
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201102968
Subject(s) - steric effects , polynucleotide , dimer , monomer , dna , minor groove , chemistry , stereochemistry , biochemistry , organic chemistry , polymer
Poly has a tracker : By sterically controlling monomer–dimer equilibria, novel dyes can kinetically differentiate between homo‐AT and alternating AT–AT polynucleotides. In this way, the width and steric occupation of the DNA minor groove can be finely probed and can be easily assessed by induced CD signals (see figure).