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Asymmetric Synthesis of β‐Adrenergic Blockers through Multistep One‐Pot Transformations Involving In Situ Chiral Organocatalyst Formation
Author(s) -
Wei Shengwei,
Messerer Regina,
Tsogoeva Svetlana B.
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201102931
Subject(s) - enantioselective synthesis , chemistry , in situ , combinatorial chemistry , computer science , stereochemistry , catalysis , organic chemistry
Two birds one stone : A new atom‐economical one‐pot approach to enantioselective chiral drug synthesis, involving in situ multistep organocatalyst formation and the application of the reaction for multistep sequential synthesis of β‐adrenergic blockers is disclosed (see scheme).