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Palladium‐Catalyzed Cascade Cyclization of Ynamides to Azabicycles
Author(s) -
Greenaway Rebecca L.,
Campbell Craig D.,
Holton Oliver T.,
Russell C. Adam,
Anderson Edward A.
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201102880
Subject(s) - cascade , palladium , scope (computer science) , modular design , computer science , scheme (mathematics) , substituent , combinatorial chemistry , chemistry , catalysis , database , organic chemistry , programming language , mathematics , chromatography , mathematical analysis
Cascade reactions : A modular assembly of azabicycles by using a cascade cyclization/Suzuki coupling/6π‐electrocyclization of bromoenynamides is reported (see scheme). The reaction offers a wide substituent scope on the bicyclic aminodiene products, which can be selectively oxidized as a general approach to aromatic azabicycles.