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Highly Selective Palladium‐Catalyzed Intramolecular Chloroamination of Unactivated Alkenes by Using Hydrogen Peroxide as an Oxidant
Author(s) -
Yin Guoyin,
Wu Tao,
Liu Guosheng
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201102776
Subject(s) - intramolecular force , hydrogen peroxide , chlorine , catalysis , chemistry , palladium , piperidine , organic chemistry , bromine , photochemistry , combinatorial chemistry
Cheap and clean! A novel Pd‐catalyzed oxidative intramolecular chloroamination of unactivated alkenes has been developed by using hydrogen peroxide as an oxidant and CaCl 2 as a chlorine source. A series of chlorinated piperidine derivatives has been obtained with high regio‐ and diastereoselectivities at room temperature (see scheme).