A Two‐Step Continuous‐Flow Synthesis of  N ‐(2‐Aminoethyl)acylamides through Ring‐Opening/Hydrogenation of Oxazolines | Zendy

Gutmann Bernhard | Zendy; Roduit JeanPaul | Zendy; Roberge Dominique | Zendy; Kappe C. Oliver | Zendy

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A Two‐Step Continuous‐Flow Synthesis of N ‐(2‐Aminoethyl)acylamides through Ring‐Opening/Hydrogenation of Oxazolines

Author(s) -

Gutmann Bernhard,

Roduit JeanPaul,

Roberge Dominique,

Kappe C. Oliver

Publication year - 2011

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201102772

Subject(s) - hydrazoic acid , ring (chemistry) , computer science , residence , scheme (mathematics) , process (computing) , chemistry , organic chemistry , mathematics , programming language , sociology , mathematical analysis , demography

Harnessing hydrazoic acid in flow! 2‐Oxazolines can be ring‐opened in a very efficient manner by treatment with in situ generated hydrazoic acid. Despite the toxic and explosive nature of hydrazoic acid, this process can be conducted safely in a continuous‐flow format with residence times as short as 5 min at 130 °C (see scheme).

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