Conformationally Stabilized Catalysts by Fluorine Insertion: Tool for Enantioselectivity Improvement | Zendy

Quintard Adrien | Zendy; Langlois JeanBaptiste | Zendy; Emery Daniel | Zendy; Mareda Jiri | Zendy; Guénée Laure | Zendy; Alexakis Alexandre | Zendy

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Conformationally Stabilized Catalysts by Fluorine Insertion: Tool for Enantioselectivity Improvement

Author(s) -

Quintard Adrien,

Langlois JeanBaptiste,

Emery Daniel,

Mareda Jiri,

Guénée Laure,

Alexakis Alexandre

Publication year - 2011

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201102757

Subject(s) - fluorine , catalysis , stereoselectivity , scheme (mathematics) , work (physics) , power (physics) , chemistry , combinatorial chemistry , expressive power , computer science , stereochemistry , organic chemistry , theoretical computer science , mathematics , engineering , physics , mechanical engineering , thermodynamics , mathematical analysis

F rigid cats : The power of conformationally stabilized catalysts is demonstrated. By taking appropriate advantage of fluorine insertion (see scheme), purely conformational catalyst design led to a notable improvement in enantioselectivities from around 70 % to 91–98.5 % ee. The other advantage of this approach is the better understanding of the origin of the stereoselectivity in the given catalytic system.

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