Formal Asymmetric Hydration of Non‐Activated Alkenes in Aqueous Medium through a “Chemoenzymatic Catalytic System” | Zendy

Schnapperelle Ingo | Zendy; Hummel Werner | Zendy; Gröger Harald | Zendy

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Formal Asymmetric Hydration of Non‐Activated Alkenes in Aqueous Medium through a “Chemoenzymatic Catalytic System”

Author(s) -

Schnapperelle Ingo,

Hummel Werner,

Gröger Harald

Publication year - 2012

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201102579

Subject(s) - enantioselective synthesis , acetophenone , catalysis , chemistry , styrene , palladium , aqueous medium , aqueous solution , combinatorial chemistry , organic chemistry , copolymer , polymer

A direct one‐pot conversion of (substituted) styrene(s) into the corresponding (substituted) ( R )‐phenylethan‐1‐ol(s) in a highly enantioselective manner has been achieved by using a “chemoenzymatic catalytic system”, comprising a palladium‐catalyzed Wacker–Tsuji oxidation and subsequent enantioselective enzymatic reduction of the in situ formed (substituted) acetophenone(s) (see scheme).

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