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Formal Asymmetric Hydration of Non‐Activated Alkenes in Aqueous Medium through a “Chemoenzymatic Catalytic System”
Author(s) -
Schnapperelle Ingo,
Hummel Werner,
Gröger Harald
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201102579
Subject(s) - enantioselective synthesis , acetophenone , catalysis , chemistry , styrene , palladium , aqueous medium , aqueous solution , combinatorial chemistry , organic chemistry , copolymer , polymer
A direct one‐pot conversion of (substituted) styrene(s) into the corresponding (substituted) ( R )‐phenylethan‐1‐ol(s) in a highly enantioselective manner has been achieved by using a “chemoenzymatic catalytic system”, comprising a palladium‐catalyzed Wacker–Tsuji oxidation and subsequent enantioselective enzymatic reduction of the in situ formed (substituted) acetophenone(s) (see scheme).