Premium
Organocatalytic Enantioselective Amination of Morita–Baylis–Hillman Carbonates with Masked Ammonia: A Facile Method for the Synthesis of Unprotected α‐Methylene‐β‐Amino Esters
Author(s) -
Lin Aijun,
Mao Haibin,
Zhu Xi,
Ge Huiming,
Tan Renxiang,
Zhu Chengjian,
Cheng Yixiang
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201102522
Subject(s) - amination , enantioselective synthesis , chemistry , allylic rearrangement , organic chemistry , cinchona , imine , catalysis , ammonia , benzophenone , combinatorial chemistry
Amination under the mask : The asymmetric allylic amination of MBH carbonates was achieved with masked ammonia (benzophenone imine) under the catalysis of modified cinchona alkaloids to give good yields with excellent enantioselectivities (up to 99 % ee ) for a wide range of MBH carbonates (see scheme).