Premium
Palladium‐Catalyzed Amidation of N ‐Tosylhydrazones with Isocyanides
Author(s) -
Zhou Fengtao,
Ding Ke,
Cai Qian
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201102459
Subject(s) - ketenimine , chemistry , palladium , catalysis , carbene , organic chemistry , combinatorial chemistry , medicinal chemistry
Aminocarbonylation of N ‐tosylhydrazones : The direct formation of ketenimines from carbenes and isocyanides is limited to the reaction of Fischer carbene complexes or some specially stabilized carbenes with isocyanides. A Pd‐catalyzed amidation of N ‐tosylhydrazones with isocyanides via a ketenimine intermediate in the presence of water is described. The method offers a general way to synthesize amides from carbonyl compounds through one‐carbon extension (see scheme).