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Selective N‐Alkylation of Amines with Alcohols by Using Non‐Metal‐Based Acid–Base Cooperative Catalysis
Author(s) -
Du Ya,
Oishi Shunsuke,
Saito Susumu
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201102446
Subject(s) - chemistry , amine gas treating , alkylation , scope (computer science) , catalysis , alcohol , base (topology) , organic chemistry , substrate (aquarium) , selectivity , metal , combinatorial chemistry , computer science , programming language , mathematical analysis , oceanography , mathematics , geology
Learning to cooperate : A straightforward method for the selective N‐mono‐ and dialkylation of amines with alcohols by means of non‐metal‐based catalysis promoted by TAPC is reported (see scheme). Selectivity of the N‐mono‐ and dialkylation, substrate scope and functional‐group tolerance are highlighted with respect to each amine (1° and 2°; aromatic and aliphatic) and alcohol (1°, 2° and 3°; benzylic and aliphatic) component.