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Ruthenium‐Catalyzed Isoquinolone Synthesis through CH Activation Using an Oxidizing Directing Group
Author(s) -
Li Bin,
Feng Huiliang,
Xu Shansheng,
Wang Baiquan
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201102445
Subject(s) - oxidizing agent , ruthenium , catalysis , limiting , chemistry , combinatorial chemistry , substrate (aquarium) , scope (computer science) , regioselectivity , group (periodic table) , medicinal chemistry , organic chemistry , computer science , biology , engineering , mechanical engineering , ecology , programming language
The oxidant directs : A mild, practical, efficient, and regioselective Ru‐catalyzed isoquinolone synthesis with a broad substrate scope was reported (see scheme). In this redox neutral process, the aromatic CH bond functionalization can be performed at room temperature without using any external oxidant. The mechanism of the reaction was probed, and it was found that CH activation is the turnover‐limiting step.