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Rhodium‐Catalyzed Asymmetric [2+2+2] Cyclization of 1,6‐Enynes and Aldehydes
Author(s) -
Ishida Mana,
Shibata Yu,
Noguchi Keiichi,
Tanaka Ken
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201102418
Subject(s) - rhodium , cationic polymerization , catalysis , enantioselective synthesis , heteroatom , chemistry , substrate (aquarium) , combinatorial chemistry , medicinal chemistry , organic chemistry , ring (chemistry) , oceanography , geology
Asymmetric catalysis : The rhodium‐catalyzed asymmetric [2+2+2] cyclization of 1,6‐enynes and aldehydes was achieved by using a cationic rhodium(I)/( R )‐binap complex as a catalyst (see scheme; cod=1,5‐cyclooctadiene). Coordination of the substrate heteroatom to the cationic rhodium plays an important role in this cyclization reaction.