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A Molecular Probe for the Highly Selective Chromogenic Detection of DFP, a Mimic of Sarin and Soman Nerve Agents
Author(s) -
Gotor Raúl,
Costero Ana M.,
Gil Salvador,
Parra Margarita,
MartínezMáñez Ramón,
Sancenón Félix
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201102241
Subject(s) - sarin , soman , nerve agent , tabun , chemistry , moiety , chromogenic , derivative (finance) , combinatorial chemistry , stereochemistry , biochemistry , chromatography , acetylcholinesterase , enzyme , business , finance
Lethal‐weapon visualization : A novel triarylmethanol derivative, which is able to colorimetrically distinguish diisopropylfluorophosphate (DFP; a mimic of Sarin and Soman) from other nerve‐agent simulants, is reported (see picture). This probe was designed to contain two reactive sites: an OH group that provides a suitable reactive group for nerve agents and a tert ‐butyldimethylsilylether moiety that is able to react with fluoride, which is a specific byproduct of the phosphorylation of OH by DFP.