Asymmetric Synthesis of  cis ‐4‐Aminobenzopyran Derivatives Catalyzed by  N , N′ ‐Dioxide–Sc(OTf) 3  Complexes | Zendy

Zhang Yulong | Zendy; Dong Shunxi | Zendy; Liu Xiaohua | Zendy; Xie Mingsheng | Zendy; Zhu Yin | Zendy; Lin Lili | Zendy; Feng Xiaoming | Zendy

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Asymmetric Synthesis of cis ‐4‐Aminobenzopyran Derivatives Catalyzed by N , N′ ‐Dioxide–Sc(OTf) 3 Complexes

Author(s) -

Zhang Yulong,

Dong Shunxi,

Liu Xiaohua,

Xie Mingsheng,

Zhu Yin,

Lin Lili,

Feng Xiaoming

Publication year - 2011

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201102058

Subject(s) - catalysis , furan , chemistry , pyran , advice (programming) , organic chemistry , combinatorial chemistry , medicinal chemistry , computer science , programming language

The reactions of salicylaldimines with electron‐rich alkenes (2,3‐dihydro‐2 H ‐furan and 3,4‐dihydro‐2 H ‐pyran) catalyzed by N,N′‐ dioxide–Sc(OTf) 3 complexes were investigated. The methodology was successfully applied to the asymmetric synthesis of cis ‐4‐aminobenzopyran derivatives. Excellent yields, diastereo‐ and enantioselectivities were observed for a broad range of substrates under mild conditions (see scheme).

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