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Organocatalytic Synthesis of 1,2,3‐Triazoles from Unactivated Ketones and Arylazides
Author(s) -
Belkheira Mokhtaria,
El Abed Douniazad,
Pons JeanMarc,
Bressy Cyril
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201102046
Subject(s) - click chemistry , chemistry , combinatorial chemistry , triazole , catalysis , computer science , organic chemistry
Organo‐click reaction : A new and complementary method to Huisgen's metal‐catalyzed triazole synthesis is described using unactivated ketones and arylazides as the substrates and proline as an organocatalyst. Dramatic acceleration was observed for this reaction using microwave activation and high regio‐ and chemoselectivities were obtained for a wide range of ketones and arylazides (see scheme).