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Dehydrogenative Heck Reaction of Furans and Thiophenes with Styrenes under Mild Conditions and Influence of the Oxidizing Agent on the Reaction Rate
Author(s) -
Vasseur Alexandre,
Muzart Jacques,
Le Bras Jean
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101992
Subject(s) - oxidizing agent , heck reaction , chemistry , medicinal chemistry , reaction rate , photochemistry , catalysis , organic chemistry , polymer chemistry , combinatorial chemistry , palladium
CH vs. CBr in Heck : The direct dehydrogenative coupling of furans and thiophenes with styrenes occurs under mild conditions (see scheme). This method allows the coupling of brominated substrates through CH bond activation. In addition, DMSO and benzoquinone had a positive effect on the reaction rate.