Efficient Preparation and Biological Evaluation of a Novel Multivalency Bifunctional Chelator for  64 Cu Radiopharmaceuticals | Zendy

Liu Shuanglong | Zendy; Li Zibo | Zendy; Yap LiPeng | Zendy; Huang ChiunWei | Zendy; Park Ryan | Zendy; Conti Peter S. | Zendy

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Efficient Preparation and Biological Evaluation of a Novel Multivalency Bifunctional Chelator for 64 Cu Radiopharmaceuticals

Author(s) -

Liu Shuanglong,

Li Zibo,

Yap LiPeng,

Huang ChiunWei,

Park Ryan,

Conti Peter S.

Publication year - 2011

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201101894

Subject(s) - bifunctional , conjugate , chelation , computer science , combinatorial chemistry , chemistry , computational biology , nanotechnology , biochemistry , biology , mathematics , materials science , organic chemistry , mathematical analysis , catalysis

A novel bifunctional chelator : The sarcophagine motif was used in the development of a novel bifunctional chelator for 64 Cu radiopharmaceuticals (see figure). The high tumor‐targeting efficiency and great stability of the 64 Cu–BaBaSar–RGD 2 conjugate were validated in a U87MG glioma xenograft mouse model.

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