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Efficient Preparation and Biological Evaluation of a Novel Multivalency Bifunctional Chelator for 64 Cu Radiopharmaceuticals
Author(s) -
Liu Shuanglong,
Li Zibo,
Yap LiPeng,
Huang ChiunWei,
Park Ryan,
Conti Peter S.
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101894
Subject(s) - bifunctional , conjugate , chelation , computer science , combinatorial chemistry , chemistry , computational biology , nanotechnology , biochemistry , biology , mathematics , materials science , organic chemistry , mathematical analysis , catalysis
A novel bifunctional chelator : The sarcophagine motif was used in the development of a novel bifunctional chelator for 64 Cu radiopharmaceuticals (see figure). The high tumor‐targeting efficiency and great stability of the 64 Cu–BaBaSar–RGD 2 conjugate were validated in a U87MG glioma xenograft mouse model.