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Screw‐Sense Control of Helical Oligopeptides Containing Equal Amounts of L ‐ and D ‐Amino Acids
Author(s) -
Demizu Yosuke,
Doi Mitsunobu,
Sato Yukiko,
Tanaka Masakazu,
Okuda Haruhiro,
Kurihara Masaaki
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101809
Subject(s) - residue (chemistry) , oligopeptide , amino acid , stereochemistry , chemistry , combinatorics , peptide , computer science , mathematics , biochemistry
Residue order is important! The preferred secondary structures of Boc‐( L ‐Leu‐ D ‐Leu‐Aib) n ‐OMe containing equal amounts of L ‐ and D ‐Leu have been investigated and the results show that these residues form right‐handed ( P ) α helices in both solution and crystalline states (see picture).