Premium
Autoinductive Exponential Signal Amplification: A Diagnostic Probe for Direct Detection of Fluoride
Author(s) -
PerryFeigenbaum Rotem,
Sella Eran,
Shabat Doron
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101796
Subject(s) - fluoride , chromogenic , analyte , signal (programming language) , exponential function , chemistry , amplifier , ion , materials science , analytical chemistry (journal) , optoelectronics , inorganic chemistry , chromatography , computer science , organic chemistry , mathematical analysis , mathematics , cmos , programming language
A new example of an exponential signal amplification strategy for the direct detection of fluoride is demonstrated. The amplification occurred through reaction of fluoride with a responsive chromogenic probe. The probe activity is based on a unique dendritic chain reaction that generates a fluoride anion, which is the analyte of interest, during the disassembly pathway of the dendritic probe. This autoinductive amplification mechanism may be applied for detection of other analytes by coupling activity of a modified probe with that of the fluoride amplifier.