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Efficient and Substrate‐Specific Hydration of Nitriles to Amides in Water by Using a CeO 2 Catalyst
Author(s) -
Tamura Masazumi,
Wakasugi Hiroko,
Shimizu Kenichi,
Satsuma Atsushi
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101576
Subject(s) - heteroatom , substrate (aquarium) , catalysis , chemistry , carbon fibers , chemical engineering , organic chemistry , combinatorial chemistry , materials science , ring (chemistry) , composite material , composite number , engineering , oceanography , geology
CeO 2 acted as a reusable and effective catalyst for the hydration of various nitriles to amides in water under neutral conditions at low temperature (30–100 °C). CeO 2 showed notable substrate specificity for nitriles that have a heteroatom adjacent to the α‐carbon atom of the CN group (see scheme).