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N ‐Acetylmethionine and Biotin as Photocleavable Protective Groups for Ruthenium Polypyridyl Complexes
Author(s) -
Goldbach Roosmarijn E.,
RodriguezGarcia Isabel,
van Lenthe Joop H.,
Siegler Maxime A.,
Bonnet Sylvestre
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101541
Subject(s) - ruthenium , thioether , ligand (biochemistry) , prodrug , chemistry , combinatorial chemistry , computer science , stereochemistry , organic chemistry , catalysis , biochemistry , receptor
Ru in a new light! A potentially biologically active aqua complex can be “hidden” by S‐coordination of N ‐acetylmethionine or biotin to ruthenium. Thus, the ruthenium–thioether complex appears as a prodrug, which can be “activated” by visible‐light irradiation (see scheme). The biologically harmless thioether ligand therefore acts as a protecting group for the aqua–ruthenium complex.