N ‐Acetylmethionine and Biotin as Photocleavable Protective Groups for Ruthenium Polypyridyl Complexes | Zendy

Goldbach Roosmarijn E. | Zendy; RodriguezGarcia Isabel | Zendy; van Lenthe Joop H. | Zendy; Siegler Maxime A. | Zendy; Bonnet Sylvestre | Zendy

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N ‐Acetylmethionine and Biotin as Photocleavable Protective Groups for Ruthenium Polypyridyl Complexes

Author(s) -

Goldbach Roosmarijn E.,

RodriguezGarcia Isabel,

van Lenthe Joop H.,

Siegler Maxime A.,

Bonnet Sylvestre

Publication year - 2011

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201101541

Subject(s) - ruthenium , thioether , ligand (biochemistry) , prodrug , chemistry , combinatorial chemistry , computer science , stereochemistry , organic chemistry , catalysis , biochemistry , receptor

Ru in a new light! A potentially biologically active aqua complex can be “hidden” by S‐coordination of N ‐acetylmethionine or biotin to ruthenium. Thus, the ruthenium–thioether complex appears as a prodrug, which can be “activated” by visible‐light irradiation (see scheme). The biologically harmless thioether ligand therefore acts as a protecting group for the aqua–ruthenium complex.

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