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Improved Syntheses of Phosphine Ligands by Direct Coupling of Diarylbromophosphine with Organometallic Reagents
Author(s) -
Liu Lei,
Wu HaiChen,
Yu JinQuan
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101467
Subject(s) - phosphine , reagent , trifluoromethanesulfonate , binap , bromide , chemistry , combinatorial chemistry , coupling (piping) , polymer chemistry , medicinal chemistry , organic chemistry , enantioselective synthesis , catalysis , materials science , metallurgy
Br versus Cl : It is found that the use of diarylbromophosphines instead of diarylchlorophosphines is crucial for their direct coupling with binaphthylmagnesium bromide or BINOL triflate. This finding has led to an improved preparation of both electron‐deficient BINAP‐type phosphine ligands and several important Buchwald's ligands.