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Harnessing Nature’s Insights: Synthetic Small Molecules with Peroxidase‐Mimicking DNAzyme Properties
Author(s) -
Stefan Loic,
Xu HaiJun,
Gros Claude P.,
Denat Franck,
Monchaud David
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101337
Subject(s) - deoxyribozyme , small molecule , hemin , porphyrin , combinatorial chemistry , chemistry , peroxidase , nanotechnology , computational biology , molecule , dna , computer science , biochemistry , enzyme , materials science , biology , heme , organic chemistry
Substitute features : The demonstration that small DNAs can acquire enzymatic properties (DNAzyme activity) is appealing since it makes protein‐based biotechnologies simpler. Herein, two further simplifications of this process are proposed: the substitution of DNAs for small molecules, called DOTA‐templated synthetic G‐quartets (DOTASQ), and of hemin for the more practically convenient iron(III) porphyrin (FeTPPS; see scheme).