A New Ratiometric Fluorescent Probe for Detection of Fe 2+  with High Sensitivity and Its Intracellular Imaging Applications | Zendy

Li Ping | Zendy; Fang Libo | Zendy; Zhou Hui | Zendy; Zhang Wen | Zendy; Wang Xu | Zendy; Li Na | Zendy; Zhong Hongbo | Zendy; Tang Bo | Zendy

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A New Ratiometric Fluorescent Probe for Detection of Fe 2+ with High Sensitivity and Its Intracellular Imaging Applications

Author(s) -

Li Ping,

Fang Libo,

Zhou Hui,

Zhang Wen,

Wang Xu,

Li Na,

Zhong Hongbo,

Tang Bo

Publication year - 2011

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201101327

Subject(s) - fluorophore , fluorescence , intracellular , sensitivity (control systems) , chemistry , fluorescence lifetime imaging microscopy , biophysics , analytical chemistry (journal) , optics , physics , biology , biochemistry , chromatography , electronic engineering , engineering

Good sense : A highly sensitive and selective ratiometric fluorescent probe for Fe 2+ was developed by linking an Fe 2+ ‐insensitive fluorophore to an Fe 2+ ‐sensitive reporter–fluorophore fragment. The fluorescence intensity ratio increased linearly with the concentration of Fe 2+ (see scheme). The probe was applied to the ratiometric imaging of intracellular and adscititious fluctuations of Fe 2+ in live HL‐7702 and HepG2 cells.

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