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Palladium‐Catalyzed Regioselective Aerobic Oxidative CH/NH Carbonylation of Heteroarenes under Base‐Free Conditions
Author(s) -
Zhang Hua,
Liu Dong,
Chen Caiyou,
Liu Chao,
Lei Aiwen
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101300
Subject(s) - regioselectivity , carbonylation , chemistry , palladium , catalysis , oxidative phosphorylation , base (topology) , oxygen , organic chemistry , medicinal chemistry , combinatorial chemistry , carbon monoxide , biochemistry , mathematical analysis , mathematics
Clearing the air! By using a balloon pressure of CO, the direct oxidative carbonylation of various heteroarenes with different alcohols was achieved in good to high yields with air as the oxidant in the presence of PdCl 2 (PPh 3 ) 2 (see scheme). Notably, this transformation was carried out under base‐free conditions. The reaction showed remarkably high regioselectivity and presents an environmentally benign protocol for the synthesis of carboxylic acid derivatives.