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Mild and Efficient Trimethylsilylcyanation of Ketones Catalysed by PNP Chloride
Author(s) -
Lacour MarieAgnès,
Rahier Nicolas J.,
Taillefer Marc
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201101195
Subject(s) - catalysis , solvent , trimethylsilyl , chemistry , organic chemistry , range (aeronautics) , computer science , materials science , composite material
Mild & green : The commercially and readily available PNPCl behaves as a very effective catalyst for the synthesis of various trimethylsilyl cyanohydrins from a wide range of aliphatic, cyclic, α,β‐unsaturated and aromatic ketones. The method proceeds at room temperature in solvent‐free conditions, in the presence of very small amounts of catalyst (see scheme).